XIdx, A dominant negative regulator of bHLH function in early Xenopus embryos

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XIdx, A dominant negative regulator of bHLH function in early Xenopus embryos

We have identified a divergent member of the Xenopus Id family, XIdx, which disrupts binding of myogenic factor/E-protein complexes to DNA in vitro and inhibits transactivation of the E-box regulated cardiac actin gene by MyoD in embryonic tissue. XIdx transcripts accumulate from the early neurula stage in discrete domains of the anterior neural plate and subsequently identify regions of the de...

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ژورنال

عنوان ژورنال: Mechanisms of Development

سال: 1995

ISSN: 0925-4773

DOI: 10.1016/0925-4773(94)00319-i